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Tuesday, 25 July 2023 09:58

Simplifying IVF: An Easy Guide to In Vitro Fertilization

Alright, let's break down this complex topic into bite-sized pieces. We're going to chat about:

  • How a tiny embryo grows outside a woman's body

  • What makes a good quality embryo

  • How doctors check if an embryo is doing well

  • How embryos are sorted into different groups

Choosing the right embryo to put into a woman's womb is like picking the winning lottery ticket. It's a big deal in the IVF process because the whole pregnancy depends on this tiny little thing. Only the strongest and healthiest embryo can stick to the womb and grow into a baby.

Not all eggs are superstars, though. Some might not be able to turn into good embryos. That's why the embryologist, the egg and embryo expert, is the MVP in the IVF process. They pick the best eggs, help them grow into embryos in a special machine called an incubator, and keep an eye on them to see which ones are doing well.

To understand how they do this, let's first look at how an embryo grows in the incubator before it's put into the womb.

How does the embryo develop outside the woman’s body?

After the eggs are collected, the embryologist cleans them up and picks the best ones. Then, they're fertilized with sperm. This can be done in two ways: in vitro, which is like a tiny swimming pool where the sperm and eggs meet, or ICSI, where one lucky sperm is chosen and injected directly into the egg.

  • About 15-17 hours later, the magic happens. The mom's and dad's genetic material start to mix. This is day zero
  • On the first day, a zygote is formed. Think of it as a single cell with all the genetic information needed to make a baby. 
  • On the second day, this cell starts to divide, making 2, 3, and finally 4 cells. It's like a tiny cell party! The doctors can already tell if the embryo is doing well by looking at the size and shape of these cells.
  • On the third day, the cell party continues, and the embryo now has 6-8 cells. Sometimes, if the embryo is doing really well, it can be put into the womb at this stage. 
  • By the fourth day, the embryo has 10-14 cells and starts to look like a little ball with a cavity inside. When this cavity gets big enough, it's called a blastocyst. 
  • On days 5-6, the blastocyst is ready to be put into the womb. As it grows, its outer layer gets thinner and eventually breaks, allowing the embryo to stick to the womb, where it will grow into a baby.

By the end of this intricate process, we've witnessed a magical journey from a single cell to a complex, ready-to-grow blastocyst, all outside the human body. Now, it's ready for its next big adventure - attaching to the womb and blossoming into life, proving that miracles aren't just born, they are carefully crafted.

What can the quality of embryos depend on?

The quality of the embryo depends on a few things. First, the health of the mom's and dad's cells. If they're healthy, the chances of having a good embryo are higher.

Next, the skills of the clinic staff and the equipment they use are important. Embryos are like tiny divas; they're super sensitive and can stop growing if something's not right.

Lastly, there's something the doctor can't control: chromosome abnormalities. These can stop the embryo from sticking to the womb or growing properly. To avoid problems, the doctor checks the embryo's quality every day, sometimes even more often.

How is the quality of the embryo evaluated?

The best way to check if an embryo is doing well is to watch it grow over time. The doctor takes the embryos out of the incubator once a day and looks at them under a microscope. They have to do this quickly because, remember, embryos are divas and don't like changes in their environment.

The doctor checks the embryos based on:

  • How they look: They should be the right shape and size, and not have any weird lumps or bumps.
  • The number of cells and their size: This should match the embryo's age.
  • The presence of non-nuclear cells: These are like extra cells that shouldn't be there.
  • The presence of intracellular inclusions: These are like unwanted guests inside the cell that can cause problems.

After each check, the doctor sorts the embryos based on their quality and chances of sticking to the womb. They keep a diary of all the changes in each embryo.

Embryo classification

It's rare for all embryos to grow perfectly, so doctors need to figure out which ones are strong and healthy. On the day of embryo transfer, usually the 5th day after fertilization, the embryos are checked and sorted into different groups. This is like the final exam to see which embryos are most likely to stick to the womb and grow into a baby.

To do this, the doctor gives each embryo a grade every day. This grade is a number (showing how old the embryo is) and two letters (the first one shows how well the baby part is forming, and the second one shows the chances of the embryo sticking to the womb and forming the placenta).

The numbers go from 1 to 6, where 1 is a young blastocyst, and 6 is a mature embryo ready to be put into the womb. The letters go from A to D, where A is a top-grade embryo, and D is not so good.

All this information is written in the embryo diary. It's a record where the embryologist writes down all the data and changes in each embryo from the first to the last day of growth.

For example, embryos graded as "3AB", "2AA", "4BB" are top students with high chances of becoming a baby, while "2BB", "2CB" are average. On the other hand, "1CD", "2CC", "2DD" are not doing so well and have a low chance of sticking to the womb.

It's important to remember that embryos graded as "2BB", "2CB" can improve and become "4BB" or "3AB" after a short time. So, it's best not to jump to conclusions until the day of transfer.

Modern Methods for Checking Embryo Quality

This grading system also helps the doctor decide if the embryo can be frozen for later. Usually, only the top-grade embryos can survive freezing and then continue to grow.

Medicine is always improving, and there are now even better ways to check on embryos. One of these is a special microscope that takes pictures of the embryos at set times. These pictures are sent to a computer, which checks how the embryos are growing and gives feedback on their quality. The best part is that the embryos don't have to be taken out of the incubator, so they're not disturbed, and their quality stays high.

Take the Next Step with Us

Alright, let's sum up. Selecting the right embryo for transfer, whether in natural conception or surrogate motherhood, is an intricate science, relying on the delicate balance of nature and the skillful precision of modern medicine. The process of grading embryos, watching them develop, and predicting their potential is fascinating, but also a responsibility of the highest order.

In the world of IVF, there are few guarantees, but with ongoing research and continual advancement in medical technologies, hope remains an integral part of the process. If you're considering surrogacy or IVF, remember, every embryo holds a potential story - a story that could become a beautiful chapter in your life.

Are you ready to explore this path? If you are, take the next step. Contact us to learn more about surrogacy and how we can help you on your journey to parenthood. Together, we can make your dreams of a family a reality. Reach out today, and let's embark on this beautiful journey together.

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Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.


Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.