Monday, 09 November 2020 07:44

Baby Born from Egg that Was Matured and Frozen in the Lab

Baby Born from Egg that Was Matured and Frozen in the Lab Baby Born from Egg that Was Matured and Frozen in the Lab

A34-year-old woman has given birth thanks to a new fertility procedure that involved collecting, maturing, and freezing some of her eggs five years earlier. Although lab-based maturation of eggs has been done before, the case study, published yesterday (February 18) in Annals of Oncology, represents the first successful pregnancy from immature eggs that were frozen after they were matured.

“We didn’t know whether or not the frozen eggs would survive and keep their potential to produce a pregnancy and live birth,” study coauthor Michaël Grynberg, head of reproductive medicine and fertility preservation at Antoine Béclère University Hospital in Paris, where the procedure was carried out, tells The Guardian. “It was a good surprise for us.”

See “Primitive Human Eggs Grown to Full Maturity in the Lab”

The woman opted for a fertility preservation treatment after being diagnosed with breast cancer at 29 years old, as chemotherapy drugs can contribute to infertility.

The standard fertility intervention for women about to receive chemotherapy consists of a procedure in which doctors administer hormones to stimulate the ovaries to produce mature eggs and then remove and store those mature eggs for later use.

In this case, the use of these hormones was deemed too risky by the woman’s doctors as the treatment might worsen her cancer. The patient also did not want to undergo surgery to have part of her ovarian tissue removed, frozen, and re-implanted after her cancer treatment, given the invasiveness of the procedure.

So researchers at Antoine Béclère University Hospital removed immature eggs from her ovaries, matured them in the lab over the course of a couple of days, and then froze them in liquid nitrogen by a process called vitrification, in which cells are rapidly cooled down to avoid the formation of destructive ice crystals.

Several years later, the doctors thawed seven of the eggs, fertilized the surviving six with sperm injections, and implanted the one resulting healthy embryo into the patient. Her baby boy, Jules, was born last summer.

“Getting eggs to mature successfully after removal from the ovary has been a challenge, so this is a very welcome positive step,” the University of Edinburgh’s Richard Anderson, who was not involved in the work, tells Yahoo. “It isn’t widely available, but this report shows it can work, when time is very short.”

Since this patient’s case, two more women being treated for cancer have had the same procedure at the hospital and are now pregnant, Grynberg tells The Guardian.

Source: https://www.the-scientist.com/

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About the author:

Susan Kersch-Kibler

Susan Kersch-Kibler is the founder of Delivering Dreams International Surrogacy Agency. She is a leading expert in ethical international surrogacy, helping to create families through surrogacy for over 2 decades in Ukraine and Ghana. Susan is a frequent keynote speaker, media commentator, and has been featured in The New York Times Magazine and National Geographic Television, among others.

She is the author of the book Successful Surrogacy and the upcoming book release “Delivering Dreams: From Infertility to Delivery in 15 Months”.

What Is Infertility?

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Thank you very much Dear Oksana, Thank you very much for the great news. We still can't believe it and are totally speechless. The work you do under these difficult conditions cannot be put into words. Thank you very much for that. Liebe Oksana, vielen Dank für die super schöne Neuigkeit. Wir können es noch gar nicht glauben und sind total sprachlos. Was Ihr für eine Arbeit leistet, unter den schweren Bedingungen,  kann man nicht in Worte fassen. Vielen herzlichen Dank dafür.
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We are thankful we found Delivering Dreams We cannot say enough good things about Delivering Dreams who took us through our surrogacy journey - egg donor matching, sperm shipping, embryo creation, IVF, surrogacy and most importantly the birth of our healthy and beautiful baby!  All of Susan's team is exceptional but of particular note is Ivan, our Customer Experience manager, who handled every aspect of our case from inception until we exited Ukraine with our baby.  Ivan is a superstar - sma...
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Gene & Amber
I just have to thank deliverying Dreams to be responsable for This miracle Hi… my name is Mariana Ribeiro and im from Brazil ! I was trying to Get pregnant for ??? last 15 years… it was a lot of exams… FIVS… a lot of bad feelings… and deceptions…. It was really hard every time i got a negative test… so we decided to try something new… surrogacy…. In Brazil ??? law is not so clear and after So much frustation i didnt want to have ??? possibility of something that could be really bad…. So we d...
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znoorist
I can't praise enough my positive experience with this exceptional team. My concern was to achieve the dream of parenthood as a single woman through legal means and without legal complications. My goal was to establish parenthood in Germany without any legal difficulties. At that time, the USA with its so-called "Prebirth Order" seemed to be the only option, allowing me to be listed as the sole parent on the birth certificate and legitimize motherhood in Germany and worldwide without legal i...
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Verregie Woman

Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.

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