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Wednesday, 13 September 2017 07:14

Fear Designer Super Babies? Genetic Embryo Testing In Ukrainian Surrogacy Already Eliminates Most Genetic Diseases

Worried about designer babies? Most of the concerns about new CRISPR gene editing breakthroughs are myths. Skills, talents and intelligence are based on a multitude of genes and 50% on the environmental "nurture" effects. Many diseases, like cancer, are not triggered by a single gene.

To prevent most genetic diseases and disorders, we at Delivering Dreams offer full 24 chromosome genetic testing of embryos implantation for all our surrogacy programs in Ukraine.

Five myths about gene editing

CRISPR’s breakthrough made headlines. But are we ready to engineer designer babies?

Gene editing made great strides this month when scientists reported success using a technique called CRISPR — Clustered Regularly Interspaced Short Palindromic Repeats — to correct a serious, disease-causing mutation in human embryos. Researchers fixed a mutation that leads to hypertrophic cardiomyopathy, a relatively common inherited disease of the heart muscle that affects about 1 in 500 people. The public response was wildly enthusiastic. But any new technology can spur confusion and hyperbole, and this one is no exception. Here are five myths about what CRISPR can and can’t do.

Myth No. 1

CRISPR can build customized babies.

In February 2016, one CRISPR critic predicted in Mother Jones, “We are this close to ‘designer babies.’ ” This month, biologist Richard Dawkins mused that the genetically edited “designer babies ” on the horizon shouldn’t be any more worrisome than children who are pushed by their parents to hone their natural talents.

But CRISPR is not on the cusp of creating a super-race for one main reason: We don’t know how to do that. We don’t know how to build baby Einsteins or order up a finely chiseled and uber-flexible Simone Biles, because there is no single “smart gene” or “spunky, lithe gymnast gene.”

Much of what goes on inside our bodies and our brains is influenced by a combination of genes and environment, nature and nurture. Beauty, athleticism and musicality don’t hinge on a single sequence of base-pairs. Instead, these characteristics are considered “complex traits” that are shaped by the input of multiple genes, along with lifestyle and environmental factors. This is especially true of intelligence. Studies, many of which have tracked adopted children and twins, have indicated that just 50 percent of the variation in intelligence among people can be chalked up to genetics.

Myth No. 2

It’s the only hope for would-be parents with genetic conditions.

The Genetic Literacy Project, a group dedicated to increasing the public’s understanding of gene research, wrote this year that “parents worried about passing on genetic disorders to their children have hope: Gene editing.” Likewise, an Australian newspaper greeted this month’s CRISPR news with an ebullient headline: “Hope for parents as science deletes mutant killer gene.”

While it’s undeniable that the ability to home in on and fix a genetic error would enable some would-be parents to sidestep the possibility of transmitting a disease to their offspring, gene editing is not the only option in such cases. Preimplantation genetic diagnosis has been used for decades to help couples who go through IVF ensure that they select healthy embryos from among those fertilized in a clinic. The technology has allowed carriers of genetic disease to conceive unaffected children, starting in 1991, when it was first used to avoid cystic fibrosis.

In the event that not enough healthy embryos are created during the IVF process, CRISPR could one day lend a helping hand and repair defective embryos, giving a couple more choices. Still, an essay that accompanied this month’s research report, published in Nature, concluded that “embryo genetic testing during IVF remains the standard way to prevent the transmission of inherited diseases in human embryos.”

Myth No. 3

CRISPR will be available for widespread use soon.

“I think it’s really likely that in the not-too-distant future it will cure genetic disease,” Jennifer Doudna, one of the scientists behind CRISPR, said at a recent conference . The Chicago Tribune’s editorial board shared the sentiment in April 2016, claiming that “for some people born with debilitating genetic diseases, scientists could give them relief from their symptoms — and maybe even cure them in the not-too-distant future.”

Not so fast. In the United States, a human-embryo research ban has been in place since 1996, prohibiting the use of federal money to support research in which embryos are created, destroyed or discarded. Recent embryo-editing studies were paid for by universities and foundations, but the lack of federal funding slows the science down.

Moreover, just because one experiment was successful doesn’t mean the next one will be. In fact, even though most embryos were successfully repaired in the recently reported study, more than a quarter weren’t. Another concern is that CRISPR may solve one problem while unintentionally creating another. A challenge is to avoid “off-target” edits or “mosaicism,” a condition that occurred in previous attempts, in which CRISPR successfully edited the specific mutation in some but not all cells. The technique needs much more practice before it’s ready for widespread public use.

Myth No. 4

CRISPR means a future without genetic diseases.

“There is widespread interest in using CRISPR, which allows the targeted editing of specific genes, to potentially end genetic disease in humans,” Vice reported in December 2015 . A more recent headline from Wired cheered that “CRISPR may cure all genetic disease — one day.”

While that would certainly be nice, it’s impossible to edit out all genetic diseases, because not all genetic diseases are simply inherited. There are about 10,000 single-gene disorders that we’ve discovered — diseases caused by a specific, individual gene mutation. But there are thousands more that are caused by multiple genetic factors. Moreover, some genetic conditions are the result of new, spontaneous changes in DNA, called “de novo” mutations.

Cancer is a prime example. While some types of cancer can be inherited, many others don’t appear to have a primary genetic component, and often respond to a variety of environmental factors and other outside causes. Ending genetic disease is a worthy goal, but an extremely complicated one that will require more than eliminating heritable disease.

Myth No. 5

CRISPR technology will one day be broadly available.

Recent advances in gene-editing technology have made the process cheaper , causing some commentators to predict a quick CRISPR proliferation on the horizon. “Gene Editing Is Now Cheap and Easy,” one 2015 headline claimed. A Wall Street Journal article concerned with amateurs imitating CRISPR’s technology likewise fretted that “DIY gene editing” is “fast, cheap — and worrisome.”

CRISPR may be cheaper than it once was, but it’s hard to foresee a future when all prospective parents who could benefit will be able to afford it. As a rule, genetic technologies are very expensive: Patients don’t pay just for the supplies used, but for doctors’ time, labor and equipment, often over a number of appointments. You don’t have to look any further than IVF to be reminded that using science to have babies costs a lot of money: The median cost of a single IVF cycle is $7,500. It is unclear whether insurance would cover CRISPR gene editing, but it’s highly unlikely considering that few pay for preimplantation genetic diagnosis — or IVF in the first place.

If CRISPR were to become a safe, accepted embryo-editing technique, it’s likely that only the well-to-do would be able to afford it, essentially making genetic diseases into diseases of poverty. It’s not too hard to imagine a wildly disparate economic playing field — a “dystopian vision,” in the words of StatNews writer Jim Kozubek, in which “these treatments will be available to only the wealthiest among us who can pay for them.”

For a more affordable surrogacy with legal protections for the intended parents from inception, contact us at Delivering Dreams. Learn if we can help you grow your family. Full genetic testing of embryos preimplantation and financing is available. 908-386-3864 This email address is being protected from spambots. You need JavaScript enabled to view it..

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We have been very satisfied, I have been comfortable at the clinic and with my doctor. I was heard. I could ask any questions. I like you have hu-mor, despite the circumstances. Great clinic. Your service has been very good. You have been a huge support and very spacious. You have been available 24 hours a day. You have the answer to all the questions we have been asked. You have accommodated our nervousness, you have rejoiced with us, you have been there throughout. I could not have wished ...
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A and S
The communication with surrogate is easy and better than what we expected. The updates are provided as scheduled with occasional surprises
The support was great. It was easy on us that the coordination was done by the delivering dreams team while being completely transparent with us on the progress. The communication with the delivering dreams team was always fast, responsive, and easy.
E and K
Thank you kate. You have been great today and all the other days ❤ you are a great team. We are very satisfied and happy for your help.
We were confident before in our choice, but this experience has confirmed beyond any doubt that we choose the best agency.
I loved working with Susan and her team and highly recommend them to anyone considering her services. She's is great at every aspect of a process and knows how to handle delicate matters.
Diana Lyakhovetska
Susan truly understands the needs of parents using surrogacy, and offers comprehensive emotional support to parents as they experience the journey!
Christine Hughes Pontier
The team at Delivering Dreams is amazing! Their attention to detail and ability to put your mind at ease while growing your family is like none other. They handled everything for us, and I never once doubted they would help us accomplish our dreams.
Margaret Jones
I’ve known Susan for several years now, and I’ve always been impressed by her attention to her clients’ needs. I’ve known her to work ardently and diligently to solve whatever challenges, no matter how unique, that prevent her clients from completing their families. She is a problem-solver, and she earnestly believes in providing the best options and in making surrogacy opportunities realities: this is not merely a business for Susan. She will help customize the process for your needs and to ...
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Mary Woods
Susan has a keen sense of business and goes to the max to solve her clients’ problems. She is super knowledgeable on business, laws and how things work in surrogacy in general, and specifically on Ukrainian surrogacy. She is an advocate for transparency in a market that’s often opaque and full of hidden risks. I really enjoyed working with Susan. She really pays attention to detail and was always looking out for my best interest above all. Highly recommend!
Laurie Tham
Delivering Dreams goes above and beyond what other surrogacy agencies offer. After speaking with Susan, I see how they anticipate every part of the process, down to details that I had never even considered. I didn’t know what I didn’t know! Surrogacy can be really complicated and confusing. What an amazing sense of relief to have a company so dedicated to managing the WHOLE process and taking away as much of the stress as possible.
Kate Varness
I have gotten to know Susan through a group where we are members. I have found her to be a genuine and caring person. Her consideration for others and love of her work with Ukrainian surrogates and parents-to-be are evident in all her decision making. She is passionate about being a force for the greater good and helping where she can. I have been amazed at the way she is able to smoothly navigate the complicated maze of requirements in the surrogacy process. I am happy to give her my highest...
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Rose Anne Barbour Huck
Susan Kibler is kind.  She clearly loves those she works with and loves what she does.  Susan listens deeply and compassionately and can make you laugh all in the space of one conversation.  She is wonderful!  If you are feeling worried, she'll hear you.  If you have questions, she will find answers for you. If you need help, she does her very best to support you.  I feel so fortunate to have found her and imagine you will too.
Frances Russell
Susan has the ability to really connect on a personal level quickly.  I have found her easy to talk to and have been so grateful for her guidance.  She is one of those people who offers so much to her clients.  She sees the big picture and has a heart for the most intimate concerns.  She is highly skilled and able to manage what can certainly be challenging and uncomfortable experiences, making them feel easier.  She will take charge at the perfect times and guide you when you really need her...
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Susan Seare
The international surrogacy world is complicated. Susan Kibler knows its ins-and-outs. She knows the people and outfits you can trust and the ones to avoid. She insists on the best for her clients and handles the details so they don't have to worry about them. If you want to take the international surrogacy journey, you can trust Delivering Dreams International Surrogacy Agency to guide you on that path.
Nancy Linnerooth
My friend and I had a positive experience working with Susan. Susan is always super responsive and caring. She is very professional, helpful and reliable. My friend has soo much troubles trying having a baby for many years. My friend and her husband were about to give up their dream of having a baby. Susan Kersch Kibler found the way to help. She has unlimited energy, attentive to detail and super efficient. Great to work with!
Polina Clend
Susan is passionate about helping people become families. She is a trustworthy confidant to have on your side.
Kristen Ancker
Our experience with Delivering Dreams has been overwhelmingly positive. The team seems to be genuinely dedicated to helping us to realize our dream of having a child. The constant communication leading up to the trip and the numerous touch points made us feel comforted in what has been a very challenging and uncomfortable situation. We always had streamlined communication through the group chat and was frequently checked on during our stay.

Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.


Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.