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Tuesday, 02 March 2021 05:04

Multiple (MET) and Double Embryo Transfers (DET) VS Single Embryo Transfers (SET)

Risks and Benefits

SET has a higher success rate than DET

Transferring one embryo into women during in vitro fertilization (IVF) doesn't lower their chances of giving birth but it does mean fewer women give birth to twins, with all the attendant health risks. (Double embryo transfers increase the occurrence of twin births from 1% to 30%)

In the past, it was recommended to implant multiple embryos in order to maintain high pregnancy rates, but improved technology has helped increase births when single embryos are used in younger women judged to have a good chance of getting pregnant.

Data for the five years of MET and SET showed that birth rates didn't suffer – they actually improved.

With multiple embryos transferred, 51% of all women younger than 38 got pregnant and gave birth to a live baby, compared with 56% with one embryo transferred.

According to the study the difference has increased further.

Among 364 women who fit the criteria and had a single-embryo transfer from 2004 on, 65% gave birth to a live baby.

According to multiple studies, including a quite recent 2017 study from the University of Colorado and Duke University, transferring one, rather than multiple fertilized eggs doubles the chances of a healthy birth.

Source: journal Fertility and Sterility. Centers for Disease Control and Prevention.

Risks to the Children of Multiple Births:

IVF with multiple eggs increases the odds of having twins or multiples, which in turn increases the chances that the babies will be born premature and underweight. The University of Colorado and Duke University collaborative study is the largest to date to look at outcomes of pregnancies using fresh and frozen donor eggs. The Colorado and Duke study is the first comprehensive comparison of the two methods, comparing outcomes for 30,000 patients who underwent IVF between the years 2012 and 2014.

(It was also found that there was no significant clinical difference in the success rates between fresh or frozen embryos. Since the use of a frozen embryo rather than a fresh embryo is a simpler process, the research suggests that frozen embryo transfers are just as viable of a choice for implantation when making decisions regarding your IVF transfer.)

While any pregnancy has risks, most risks are considerably increased with multiple birth.

Single deliveries are associated with:

  • 9% risk of low birth weight,
  • 2% risk of very low birth weight, and
  • 14% risk of a premature birth,

With twin births these same risks increase to

  • 57% risk of low birth weight, (a 533% increase)
  • 9% risk of very low birth weight, and (a 350% increase)
  • 65% risk of a premature birth (a 354% increase)
  • neurological disorders (see study below)
  • birth defects (see study below)

With triplet birth, these risks are 96%, 34%, and 97% respectively.

Twin babies are seven times more likely to die in the neonatal period (from birth until 28 days) compared with single born children. As one would expect, with an increase in the size of the multiple birth (triplets, etc.) comes an increase in these risks.

Source: Centers for Disease Control and Prevention.

Low birth weight and premature birth can affect survival and well-being of newborns. These babies may require special care immediately after birth and at times, can face life-long problems such as developmental disabilities and delays.

The risks of low birth weight and premature birth are not to be ignored as short term. They can cause numerous other long-term risks, which include prolonged hospitalization, mental disabilities, cerebral palsy, respiratory distress, visual issues, digestive disorders, hearing loss, jaundice, bleeding in the brain, neonatal death, and increased risks during adulthood such as adult death from heart disease.

Born prematurely, multiples may be possibly missing out on a period of in-utero development critical for grey matter development in the brain. As a result, prematurity has been associated with lower cognitive function as you can see in analysis that appeared in the Journal of The American Medical Association.

Surrogate Mother Risks With Multiple Births Multiple (MET) and Double Embryo Transfers (DET) VS Single Embryo Transfers (SET)

Surrogate Mother Risks With Multiple Births Include:

  • pregnancy induced hypertension / pre-eclampsia
  • gestational diabetes
  • anemia
  • Cesarean section
  • Blood loss during delivery
  • Longer recovery period after birth

Currently, the CDC and the American Society for Reproductive Medicine’s (ASRM) guidelines recommend that only one embryo should be transferred at a time.

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Doyles
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Diana Lyakhovetska
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Christine Hughes Pontier
The team at Delivering Dreams is amazing! Their attention to detail and ability to put your mind at ease while growing your family is like none other. They handled everything for us, and I never once doubted they would help us accomplish our dreams.
Margaret Jones
I’ve known Susan for several years now, and I’ve always been impressed by her attention to her clients’ needs. I’ve known her to work ardently and diligently to solve whatever challenges, no matter how unique, that prevent her clients from completing their families. She is a problem-solver, and she earnestly believes in providing the best options and in making surrogacy opportunities realities: this is not merely a business for Susan. She will help customize the process for your needs and to ...
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Mary Woods
Susan has a keen sense of business and goes to the max to solve her clients’ problems. She is super knowledgeable on business, laws and how things work in surrogacy in general, and specifically on Ukrainian surrogacy. She is an advocate for transparency in a market that’s often opaque and full of hidden risks. I really enjoyed working with Susan. She really pays attention to detail and was always looking out for my best interest above all. Highly recommend!
Laurie Tham
Delivering Dreams goes above and beyond what other surrogacy agencies offer. After speaking with Susan, I see how they anticipate every part of the process, down to details that I had never even considered. I didn’t know what I didn’t know! Surrogacy can be really complicated and confusing. What an amazing sense of relief to have a company so dedicated to managing the WHOLE process and taking away as much of the stress as possible.
Kate Varness
I have gotten to know Susan through a group where we are members. I have found her to be a genuine and caring person. Her consideration for others and love of her work with Ukrainian surrogates and parents-to-be are evident in all her decision making. She is passionate about being a force for the greater good and helping where she can. I have been amazed at the way she is able to smoothly navigate the complicated maze of requirements in the surrogacy process. I am happy to give her my highest...
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Rose Anne Barbour Huck
Susan Kibler is kind.  She clearly loves those she works with and loves what she does.  Susan listens deeply and compassionately and can make you laugh all in the space of one conversation.  She is wonderful!  If you are feeling worried, she'll hear you.  If you have questions, she will find answers for you. If you need help, she does her very best to support you.  I feel so fortunate to have found her and imagine you will too.
Frances Russell
Susan has the ability to really connect on a personal level quickly.  I have found her easy to talk to and have been so grateful for her guidance.  She is one of those people who offers so much to her clients.  She sees the big picture and has a heart for the most intimate concerns.  She is highly skilled and able to manage what can certainly be challenging and uncomfortable experiences, making them feel easier.  She will take charge at the perfect times and guide you when you really need her...
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Susan Seare
The international surrogacy world is complicated. Susan Kibler knows its ins-and-outs. She knows the people and outfits you can trust and the ones to avoid. She insists on the best for her clients and handles the details so they don't have to worry about them. If you want to take the international surrogacy journey, you can trust Delivering Dreams International Surrogacy Agency to guide you on that path.
Nancy Linnerooth
My friend and I had a positive experience working with Susan. Susan is always super responsive and caring. She is very professional, helpful and reliable. My friend has soo much troubles trying having a baby for many years. My friend and her husband were about to give up their dream of having a baby. Susan Kersch Kibler found the way to help. She has unlimited energy, attentive to detail and super efficient. Great to work with!
Polina Clend
Susan is passionate about helping people become families. She is a trustworthy confidant to have on your side.
Kristen Ancker
Our experience with Delivering Dreams has been overwhelmingly positive. The team seems to be genuinely dedicated to helping us to realize our dream of having a child. The constant communication leading up to the trip and the numerous touch points made us feel comforted in what has been a very challenging and uncomfortable situation. We always had streamlined communication through the group chat and was frequently checked on during our stay.
Marilyn

Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.

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Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.