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Wednesday, 16 May 2018 14:20

What Can AI Do For IVF?

By Carol Lynn Curchoe, Charles L. Bormann

Up to two thirds of in vitro fertilization patients experience failed cycles but AI systems might be able to flag the most viable embryos far better than humans can.  

Infertility treatment is an emotional and financial rollercoaster. For couples trying to conceive (“TTC” in the many on-line support forums), repeated failure of implantation, defined as three or more failed in vitro fertilization (IVF) cycles where no clear cause can be identified, is a frequent, heartbreaking end point when the emotional, physical or financial burden of treatment becomes too high to keep looking for an answer. By some estimates, up to two thirds of patients experience failed cycles.

That means there’s a lot of opportunity to improve in a field where every small advance in technology represents a chance to make a family. A new infertility-related artificial intelligence (AI) startup thinks it can do just that—and some of the biggest players in computing are betting big that they are right.

AI is already being used to try and solve some big health care challenges. For example, IBM has developed a computational model that predicts heart failure, and has lent use of the Watson supercomputer to Memorial Sloan Kettering Cancer Center in New York to develop cancer-diagnosis and selection-of-treatment plans. Referred to as “Watson for Genomics,” the project ingests approximately 10,000 scientific articles and 100 new clinical trial reports every month, regularly generating new insights. Stanford University has reported a deep learning algorithm that predicts the safety of drug compounds and another to predict lung cancer type and patient survival. And Intel recently announced a competition to find an algorithm for early detection of lung cancer.

The idea of applying AI to infertility has been around for two decades. The closest solution currently available is the FDA-approved Eeva test, which uses time-lapse imaging microscopy to collect data over the length of the embryo’s culture period, and an algorithm to predict which embryo has the best chance of progressing.

That’s not true AI, though, because the algorithm is static—it doesn’t adapt when confronted with new information. A true AI system uses “deep learning” to refine itself on the fly based on new information. The “learning” in deep learning is achieved through training: hundreds or thousands of data points are fed into the model, so that future outcomes can be predicted and then the predictions are compared against actual outcomes, and the model then readjusts itself. Input values can be text, sound, signals and, most importantly for medical applications, images.

AI systems for IVF are still in the experimental phase, but the results so far have been promising. In one, for example, the system used imaging with cow embryos to identify the ones most likely to survive. Overall, the artificial intelligence system had a 76 percent accuracy rating, catching small details that signaled poor quality embryos human evaluators couldn’t see.

For human infertility, a new AI start-up, Life Whisperer, is poised to address the challenge of moving AI from the theoretical and experimental to real human embryos. Steve Wozniak (co-founder of Apple) named Life Whisperer as the Global Winner in the Talent Unleashed Awards’ “Best Idea—One to Watch” category.

Start-up companies, of course, have no mandate to publish their results for peer review. Life Whisperer says that retrospective trials conducted with its commercial partner Monash IVF have shown a “high level of accuracy level in identifying viable embryos”—which could mean almost anything.

Moreover, identifying viable embryos is only the first hurdle in IVF. Those embryos then have to be transferred into a human host—and women struggling with infertility are typically older than 35, have often experienced repeated implantation failure with no explanation, and may have known fertility issues, such as endometriosis.

A true “end-to-end” AI for infertility care will have to integrate complex (and diverse) datasets that are currently managed in multiple, incompatible systems—patient demographics and medical histories; drug-treatment regimens, pre-implantation genetic screening; and clinical pregnancy outcome data. It would help physicians to choose among several treatment options that have the highest success rates, and accept new information based on the patient’s responses to treatments.
In clinical embryology, we don’t yet know the feature or set of features that are most predictive of IVF success. It is possible that the most important variable for a successful IVF cycle could still be unknown to science—but that could in principle be uncovered by an AI system. Certainly, one caveat plagues the field of medical AI: we don’t know what we don’t know, and human experts have to “train” AIs, leading to potential amplification of our own biases, or completely overlooking certain types of data. AI technologies have tremendous potential to help the field of infertility medicine to transcend its current narrow focus on individual embryos and uncover new patterns hidden in the patient data for the treatment of stubborn infertility. 

Learn more about international surrogacy

Delivering Dreams helps couples throughout the US struggling with infertility have children. Located in NJ and Kyiv Ukraine, our amazing medical facilities and professionals, surrogates and donors are in Ukraine, because Ukrainian law protects the rights of parents and their children from inception at affordable costs and high success rates.

Unique to Delivering Dreams, we offer guaranteed not to exceed, all-inclusive pricing and contracts under US law to provide prospective parents legal and financial security.

1 in 6 couples are struggling with infertility. You are not alone. We want to be your path to parenthood.

Would you like to learn more? Please contact us to share your challenges, ask questions and discuss solutions. This email address is being protected from spambots. You need JavaScript enabled to view it., 1.908.386.3864.

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I’ve known Susan for several years now, and I’ve always been impressed by her attention to her clients’ needs. I’ve known her to work ardently and diligently to solve whatever challenges, no matter how unique, that prevent her clients from completing their families. She is a problem-solver, and she earnestly believes in providing the best options and in making surrogacy opportunities realities: this is not merely a business for Susan. She will help customize the process for your needs and to ...
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Mary Woods
Susan has a keen sense of business and goes to the max to solve her clients’ problems. She is super knowledgeable on business, laws and how things work in surrogacy in general, and specifically on Ukrainian surrogacy. She is an advocate for transparency in a market that’s often opaque and full of hidden risks. I really enjoyed working with Susan. She really pays attention to detail and was always looking out for my best interest above all. Highly recommend!
Laurie Tham
Delivering Dreams goes above and beyond what other surrogacy agencies offer. After speaking with Susan, I see how they anticipate every part of the process, down to details that I had never even considered. I didn’t know what I didn’t know! Surrogacy can be really complicated and confusing. What an amazing sense of relief to have a company so dedicated to managing the WHOLE process and taking away as much of the stress as possible.
Kate Varness
I have gotten to know Susan through a group where we are members. I have found her to be a genuine and caring person. Her consideration for others and love of her work with Ukrainian surrogates and parents-to-be are evident in all her decision making. She is passionate about being a force for the greater good and helping where she can. I have been amazed at the way she is able to smoothly navigate the complicated maze of requirements in the surrogacy process. I am happy to give her my highest...
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Rose Anne Barbour Huck
Susan Kibler is kind.  She clearly loves those she works with and loves what she does.  Susan listens deeply and compassionately and can make you laugh all in the space of one conversation.  She is wonderful!  If you are feeling worried, she'll hear you.  If you have questions, she will find answers for you. If you need help, she does her very best to support you.  I feel so fortunate to have found her and imagine you will too.
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Susan has the ability to really connect on a personal level quickly.  I have found her easy to talk to and have been so grateful for her guidance.  She is one of those people who offers so much to her clients.  She sees the big picture and has a heart for the most intimate concerns.  She is highly skilled and able to manage what can certainly be challenging and uncomfortable experiences, making them feel easier.  She will take charge at the perfect times and guide you when you really need her...
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The international surrogacy world is complicated. Susan Kibler knows its ins-and-outs. She knows the people and outfits you can trust and the ones to avoid. She insists on the best for her clients and handles the details so they don't have to worry about them. If you want to take the international surrogacy journey, you can trust Delivering Dreams International Surrogacy Agency to guide you on that path.
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Susan is passionate about helping people become families. She is a trustworthy confidant to have on your side.
Kristen Ancker
Our experience with Delivering Dreams has been overwhelmingly positive. The team seems to be genuinely dedicated to helping us to realize our dream of having a child. The constant communication leading up to the trip and the numerous touch points made us feel comforted in what has been a very challenging and uncomfortable situation. We always had streamlined communication through the group chat and was frequently checked on during our stay.
Marilyn

Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.

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Under Ukrainian law, surrogacy is a legal affordable option for traditionally married couples to have children using their own embryos, or with either an egg or sperm donor. There must be a medical reason you can’t carry a child. You are also able to participate if you have had 4 unsuccessful IVF attempts.